Words . . . Words . . . Words . . . Wait! Beef and Cheese Are Good for You?!

Nutrient Fund in Beef and Dairy Improves Immune Response to Cancer: Study
Medical Xpress / University of Chicago / Nature | Nov. 22, 2023 | Jing Chen et al.

Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a study.

The study also shows that patients with higher levels of TVA circulating in the blood responded better to immunotherapy, suggesting that it could have potential as a nutritional supplement to complement clinical treatments for cancer.

For the new study, Hao Fan, Ph.D. and Siyuan Xia, Ph.D., started with a database of around 700 known metabolites.

They screened the compounds in this new library for their ability to influence anti-tumor immunity by activating CD8+ T cells, a group of immune cells critical for killing cancerous or virally-infected cells.

After the scientists evaluated the top six candidates in both human and mouse cells, they saw that TVA performed the best. TVA is the most abundant trans fatty acid present in human milk, but the body cannot produce it on its own.

Feeding mice a diet enriched with TVA significantly reduced the tumor growth potential of melanoma and colon cancer cells compared to mice fed a control diet. The TVA diet also enhanced the ability of CD8+ T cells to infiltrate tumors.

The team also performed a series of molecular and genetic analyses.

Finally, the team worked to analyze blood samples taken from patients undergoing CAR-T cell immunotherapy treatment for lymphoma.

They saw that patients with higher levels of TVA tended to respond to treatment better than those with lower levels. They also tested cell lines from leukemia and saw that TVA enhanced the ability of an immunotherapy drug to kill leukemia cells.

The study suggests that TVA could be used as a dietary supplement to help various T cell-based cancer treatments.

Cheeseburger Is Paradise!

I’m Just Proud

Remarks by President Biden Urging Congress to Pass His National Security Supplemental Request, Including Funding to Support Ukraine

whitehouse.gov | Dec. 06, 2023

This cannot wait.  Congress needs to pass supplemental funding for Ukraine before they break for the holiday recess.  It’s as simple as that. 

Frankly, I think it’s stunning that we’ve gotten to this point in the first place. 

… Russian forces are committing war crimes.  It’s as simple as that.  It’s stunning.

I just did a meeting with the G7, which was one of the issues we discussed — all of the European leaders.  We are prepared to stay with us — stay with Ukraine, and our European friends are as well. 

Make no mistake: …

I’ll say it again: …

Let me be clear: …

The White House’s own website put in the following “[sic]”, which may be a first for them:

And my team has been engaged in negotiations with Semate [sic] — with Senate Democrats and Republicans …

… {TeleprompTer hasn’t scrolled down yet, has it?}

We can’t let Putin win.  I’ll say it again: We can’t let Putin win.

And, literally, the entire world is watching.  The entire world is watching.

Let me be clear: We need real solutions.  I support real solutions …

Republicans have to decide if they want a political issue or if they want a solution at the border.  Do they really want a solution?  It cannot be sustained as it is now.

We need a real solution. 

That’s not the answer.  That’s not the answer. 

Wait — knee-deep malarkey warning:

This is too serious.  And like I said, I am willing to make significant compromises on the border.  We need to fix the broken border system.  It is broken.  And thus far, I’ve gotten no response.

There’s polling by the Associated Press that shows that almost 70 percent of Americans, including 40 percent of Democrats, believe that you acted either illegally or unethically in regards to your family’s business interests.

Can you explain to the Americans — to Americans, amid this impeachment inquiry, why you interacted with so many of your son and brother’s foreign business associates?

THE PRESIDENT:  I’m not going to comment on that.  I did not, and it’s just a bunch of lies.

Q    You didn’t interact with many of his —

THE PRESIDENT:  I — they’re lies.

Q    — their business associates?

THE PRESIDENT:  I did not.   They’re lies.

Thank you.

Q    Mr. President, do you think there is any Democrat who could defeat Donald Trump other than you?

THE PRESIDENT:  Probably 50 of them.

Q    You do believe that there —

THE PRESIDENT:  No, I’m not the only one who can defeat him, but I will defeat him.

What’s Walrus Building?

It is done! Man was that a job. So often getting one piece in place properly popped another one out somewhere else. It was quite frustrating resulting in me having to glue key areas so they wouldn’t pop out on me.

After the problem of the exhausts was solved the above was the next big problem. The turrent ring attachments were too tight and would pop out connections. I eventually had to alter the placement of the posts in reverse of the instructions so they would fit properly. Someone messed up the instructions.

I had to do the turret plating twice to get it to sit properly on the chassis. Once again being frustrating by having to apply pressure to lock on set of bricks which would pop out other connected ones elsewhere. It is something I’ve come to expect but hate about these builds. On some it doesn’t happen and on others it seems to happen every 10 minutes. The Tiger was especially so. But it is done!

It is one big mother for sure. Now on to the next build for which I have 6 models on deck. I think it will be the motorized Panther since I have never built a moving one. When I actually start it depends upon the Holiday season and what is taking up my time.

Previouis Build

M4A3E8 Sherman Easy Eight
The M4 Sherman is, by a comfortable margin, the most recognisable of the Allied tanks of World War II (at least to a Western audience). Thousands were built and supplied to all the major Allied powers, and their combat performance was, if not spectacular, thoroughly satisfactory, with the sheer number of available vehicles being a significant contributor to the eventual defeat of Nazi Germany. Of the many, many Sherman variants that would be developed, one of the most famous (and effective) was the M4A3E8 – more formally the M4A3(76)W HVSS, known for the sake of convenience and sanity as the ‘Easy Eight’ (from the E8 suffix and comfortable ride).

The Easy Eight was arguably the most well-rounded of the Second World War Sherman variants, combining welded hull construction and wet ammunition storage for survivability with the mobility of the smooth-riding Horizontal Volute Spring Suspension (HVSS) system and attendant wider tracks, and the anti-tank punch of the excellent 76mm Gun M1. Specifically designed to counter the increasingly heavy German armour encountered as US forces pushed towards Germany, the Easy Eight was capable of engaging and destroying all marques of Panzer IVs at combat ranges, and the 76mm gun could usually threaten the heavier German tanks from the sides and rear. Against the lighter opposition encountered on other fronts, they proved absolutely devastating, although most were deployed to Western Europe. With around 2,500 made, there were never enough to go around, the type never completely replaced the 75mm-armed types in service during the Second World War (although the excellent high explosive rounds available to the 75mm meant that having a mix of the two types in the same unit was often considered beneficial), but the Easy Eight was at its core still a Sherman, with all the reliability and consistency that name entailed. Well-liked by its crews, it was considered a potent and viable weapon, although it did not completely address the demand for more firepower in armoured units, this need increasingly being filled by the Tank Destroyer branch. A good number were also deployed during the war by Canadian units.

As an excellent, reliable medium tank, the Easy Eight unsurprisingly remained in service post-war, and would be deployed in significant numbers and see combat with a number of operators in the Korean War, maintaining its reputation as a rugged, reliable machine despite being rendered technically obsolescent by tanks such as the Centurion and Pershing. Not fully retired from US service until 1957, the Easy Eight would also enjoy a surprisingly long life in other militaries across the world. As surplus World War II US military hardware flooded the export market in the late 1940s and into the 1950s, ‘Easy Eights’ would go on to serve with many countries, seeing particularly heavy service in Israeli colours, and continue to see limited action until well into the 1970s and beyond, albeit often modified far beyond their original configuration. Most recently, an Easy Eight was the star of the film Fury – while much of the historicity may be a little dubious, it does give us plenty of lovely shots of a real example of the tank in ‘action’.