Via Think Geek: Firefly Clue

The ship is quiet… too quiet. Something is off. Something is wrong. Someone is missing. It’s River! Everyone checks again, but River is nowhere to be found on Serenity. She’s not in the Cargo Bay; she’s not in the Kitchen. Everyone gathers together to figure out what in tarnation is going on. Fingers point, accusations fly, and clues are searched for. That’s right, you’re looking at Firefly Clue.
River has been betrayed and handed over to the Alliance! Now with Firefly Clue, help the Serenity crew discover who is working with the Alliance, what they used to betray River, and where on Serenity the kidnapping took place. Was it Inara with the Med Kit in the Engine Room? Or Mal with the Leather Necklace in the passenger dorm? Solve the mystery and save River! Amygdala not included.
If you’re gonna get it, get it quick, before some soulless broadcasting conglomerate cancels it.

I usually don’t cotton to movie versions of games but the Harry Potter Clue was a surprisingly good adaptation.